Want to Know More About mRNA Before Your COVID Jab? | MedPage Today
“A possible concern could be that some mRNA-based vaccine platforms induce potent type I interferon responses, which have been associated not only with inflammation but also potentially with autoimmunity,” they wrote. “Thus, identification of individuals at an increased risk of autoimmune reactions before mRNA vaccination may allow reasonable precautions to be taken.”
The authors also noted that extracellular RNA could contribute to edema, and cited a study that showed it “promoted blood coagulation and pathological thrombus formation.”
“Safety will therefore need continued evaluation as different mRNA modalities and delivery systems are utilized for the first time in humans and are tested in larger patient populations,” they wrote in the paper, which was published in 2018.